Your script is often under a specific folder (i.e publichtml/main/index.html). To access then your main page , you have to key in the exact location of your homepage (i.e www.yourdomain.com/main/index.html) . What are ways to get around this folder so that you need only to type your domain name without the complete URL (i.e. www.yourdomain.com) ?

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There are 2 ways to do this on htaccess file.

You can do a permanent redirect:
redirect 301 /index.html http://www.yourdomain.com/main/index.html

Or using URL rewrite, do something like:
RewriteRule ^index.html$ main/index.html [nc]

I suggest you use the first option if you run multiple domain names on a single site. In that way search engines will not penalize your site on publishing duplicate contents.