I tend to use 'liquid layouts' - coding with CSS make this very easy.
Tabled layouts take longer to load and are not as accessible but you can use percentages for width instead of fixed widths.
Basically, you do have to design for the lowest common denominator (800 x 600 res; Internet Explore-urgh) but if you have visitors with much higher resolution monitors, a fixed-width of say 750px looks ridiculous on their screen. Liquid layouts take care of this very easily to keep everyone happy.
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